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4-Amino-3-Nitrophenol → 2-Nitro-4-(4-(3-pyridyl)pyrimidin-2-yloxy)phenylamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Amino-3-Nitrophenol | HCID 3758882 | — |
| 反応物 | 2-Chloro-4-(pyridin-3-yl)pyrimidine | HCID 11805543 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-Nitro-4-(4-(3-pyridyl)pyrimidin-2-yloxy)phenylamine | HCID 22041340 | — |
反応手順
A solution of 4-amino-3-nitro-phenol (1 eq) and 2-chloro-4-(3-pyridyl)pyrimidine (1 eq) in N,N-dimethylformamide was microwaved at 150° C. for 10 mins. The reaction mixture was partitioned between ethyl acetate and water. The organic layer was concentrated and purified on silica gel to yield 2-nitro-4-(4-(3-pyridyl)pyrimidin-2-yloxy)phenylamine. MS: MH+=309.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07728010B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-58cd6e076cab44f498affe8c636383fd |
| 出典メモ | uspto-grants-2010_06 |