関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | p-Fluoronitrobenzene | HCID 9590 | — |
| 反応物 | 4-(Dimethylamino)piperidine dihydrochloride | HCID 22591440 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | N,N-dimethyl-1-(4-nitrophenyl)piperidin-4-amine | HCID 11086151 | — |
反応手順
Dimethyl-piperidin-4-yl-amine dihydrochloride (Aldrich, 2.0 g, 9.95 mmol) and 4-fluoro-nitrobenzene (Aldrich, 2.5 g, 17.7 mmol) were added to methanol (30 mL). The mixture was heated to 90° C. and stirred for 3.5 hours. The mixture was treated with 1 N HCl to pH=1 and then extracted with diethyl ether (2×10 mL). The aqueous layer was treated with saturated sodium carbonate to pH=10 and then extracted with methylene chloride (2×20 mL). The organic layer was dried with sodium sulfate and the solvent was removed to give the desired product. 1.25 g, 50%. MS (m+H)+: 250.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07211576B2 |
|---|
| 出典データセット | uspto-grants-2007_05 |
|---|
| ORD ID | ord-7a4df0aa5ce14d80a59cf2829f16ebe3 |
|---|
| 出典メモ | uspto-grants-2007_05 |
|---|
