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Water → [1-(4-Isothiocyanato-phenyl)-piperidin-4-yl]-dimethyl-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | N,N-dimethyl-1-(4-nitrophenyl)piperidin-4-amine | HCID 11086151 | — |
| 反応物 | Thiocarbonyl diimidazole | HCID 11412697 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | [1-(4-Isothiocyanato-phenyl)-piperidin-4-yl]-dimethyl-amine | HCID 21091577 | — |
反応手順
Dimethyl-[1-(4-nitro-phenyl)-piperidin-4-yl]-amine (Example 2, 1.1 g, 5.0 mmol) was dissolved in DMF (5 mL). To the stirred solution, thiocarbonyl diimidazole (Aldrich, 1.18 g, 90%, 6 mmol) was added and the solution was stirred at room temperature for 80 minutes. The mixture was poured into water and extracted with diethyl ether. The extract was dried with sodium sulfate and concentrated to give a pale yellow solid. 1.12 g, 85%. MS (m+H)+: 262.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07211576B2 |
| 出典データセット | uspto-grants-2007_05 |
| ORD ID | ord-96af6633f0ff44f3afb9eaf504ffa333 |
| 出典メモ | uspto-grants-2007_05 |