Diethylamine → 4-diethylaminomethyl-6-(4-fluoro-3-methylphenyl)-2-isobutyl-2H-pyridazin-3-one

HRID 1348730ノート

反応式

HRID 1348730 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([CH2:19]OS(C)(=O)=O)[C:11](=[O:18])[N:12]([CH2:14][CH:15]([CH3:17])[CH3:16])[N:13]=2)=[CH:4][C:3]=1[CH3:25].[CH2:26]([NH:28][CH2:29][CH3:30])[CH3:27]>>[CH2:26]([N:28]([CH2:19][C:10]1[C:11](=[O:18])[N:12]([CH2:14][CH:15]([CH3:17])[CH3:16])[N:13]=[C:8]([C:5]2[CH:6]=[CH:7][C:2]([F:1])=[C:3]([CH3:25])[CH:4]=2)[CH:9]=1)[CH2:29][CH3:30])[CH3:27]

参加物

3

反応物 2

HCID 8021DiethylamineHCID 219914576-(4-Fluoro-3-methylphenyl)-2-isobutyl-4-methane-sulfonyloxymethyl-2H-pyridazin-3-one

生成物 1

HCID 219915944-diethylaminomethyl-6-(4-fluoro-3-methylphenyl)-2-isobutyl-2H-pyridazin-3-one

実験手順

Following the procedure of Example 9(4), 6-(4-fluoro-3-methylphenyl)-2-isobutyl-4-methanesulfonyloxymethyl-2H-pyridazin-3-one and diethylamine were reacted to yield the title compound as a slightly yellow oil (yield: 94.7%).

後処理

  1. customwere reacted

出典と根拠

ORDレコード
ord-6d7341e168c342b584ffedc365f2eb9a
出典データセット
uspto-grants-2007_05
特許番号
US07211577B2

反応ノート

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