3-(2-Chlorophenyl)-1-propanol methanesulfonate → 4-carboxy-2-[3-(2-chlorophenyl)propyl]-6-(4-fluoro-3-methylphenyl)-2H-pyridazin-3-one

HRID 1348789ノート

反応式

HRID 1348789 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:15]([O:17]C)=[O:16])[C:11](=[O:14])[NH:12][N:13]=2)=[CH:4][C:3]=1[CH3:19].CS(O[CH2:25][CH2:26][CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=1[Cl:34])(=O)=O>>[C:15]([C:10]1[C:11](=[O:14])[N:12]([CH2:25][CH2:26][CH2:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=2[Cl:34])[N:13]=[C:8]([C:5]2[CH:6]=[CH:7][C:2]([F:1])=[C:3]([CH3:19])[CH:4]=2)[CH:9]=1)([OH:17])=[O:16]

参加物

3

反応物 2

HCID 196884483-(2-Chlorophenyl)-1-propanol methanesulfonateHCID 219914596-(4-fluoro-3-methylphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one

生成物 1

HCID 225622184-carboxy-2-[3-(2-chlorophenyl)propyl]-6-(4-fluoro-3-methylphenyl)-2H-pyridazin-3-one収率 76.8%

実験手順

Following the procedure of Example 1(6), 6-(4-fluoro-3-methylphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one and 3-(2-chlorophenyl)-1-propanol methanesulfonate were reacted to yield a crude product. Without purification, the crude product was reacted further in accordance with the procedure of Example 1(7) to yield the title compound as a yellow crystalline powder (76.8%).

後処理

  1. customwere reacted
  2. customto yield a crude product
  3. customWithout purification
  4. customthe crude product was reacted further in accordance with the procedure of Example 1(7)

出典と根拠

ORDレコード
ord-08a31690938d47f3b940a102fa15c6c3
出典データセット
uspto-grants-2007_05
特許番号
US07211577B2

反応ノート

読み込み中…