Ethanol → HCID 69141826、化合物

HRID 1348949ノート

反応式

HRID 1348949 の反応式
[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH:11]([C:16]3[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=3)[CH2:12][C:13]([OH:15])=[O:14])[CH:9]=2)[CH2:4][CH2:3][NH:2]1.C(=O)(O)[O-].[Na+].[CH2:27](O)[CH3:28]>Cl>[CH2:27]([O:14][C:13](=[O:15])[CH2:12][CH:11]([C:8]1[CH:9]=[C:10]2[C:5]([CH2:4][CH2:3][NH:2][CH2:1]2)=[CH:6][CH:7]=1)[C:16]1[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=1)[CH3:28]

参加物

5

反応物 3

HCID 702EthanolHCID 516892Sodium BicarbonateHCID 210924353-(1,2,3,4-Tetrahydro-isoquinolin-7-yl)-3-(pyrid-4-yl)-propionic acid

生成物 1

HCID 69141826HCID 69141826、化合物

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid触媒

実験手順

A solution of 3-(1,2,3,4-tetrahydro-isoquinolin-7-yl)-3-(pyrid-4-yl)-propionic acid, enantiomer A {Reference Example 18(a)} in ethanol (50 mL) was treated with concentrated hydrochloric acid (two drops) and then heated at reflux temperature, under nitrogen, for 8 hours. The pH of the reaction mixture was adjusted to ˜5 by dropwise addition of sodium bicarbonate solution (5%) and this mixture was then evaporated to give the title compound which was used without further purification.

後処理

  1. temperatureheated
  2. temperatureat reflux temperature
  3. customthis mixture was then evaporated

出典と根拠

ORDレコード
ord-824b961eb6544d678e784cde14d7b3a3
出典データセット
uspto-grants-2007_05
特許番号
US07211586B2

反応ノート

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