関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methyl iodide | HCID 6328 | — |
| 反応物 | 4-Isothiocyanatobenzoic acid | HCID 242946 | — |
| 反応物 | 4-(3-Amino-4-methylamino-phenoxy)-pyridine-2-carboxylic acid methylamide | HCID 17755838 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Benzoic Acid | HCID 243 | — |
反応手順
To {4-[3-amino-4-(methylamino)phenoxy](2-pyridyl)}-N-methylcarboxamide (1 eq) in methanol was added 4-isothiocyanatobenzoic acid (1 eq) and stirred at 60° C. for 3 h. To it was then added iodomethane (1 eq) and heated to 60° C. for 3 h. and concentrated the solvent and purified on silica gel to yield 4-({1-methyl-5-[2-(N-methylcarbamoyl)(4-pyridyloxy))]benzimidazol-2-yl}amino)benzoic acid. MS: MH+=417.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07728010B2 |
|---|
| 出典データセット | uspto-grants-2010_06 |
|---|
| ORD ID | ord-0db3fcedba7b4eb1b027317ca6693d87 |
|---|
| 出典メモ | uspto-grants-2010_06 |
|---|
