2,1,3-Benzothiadiazol-4-amine → (2S,4EZ)-N-(2,1,3-benzothiadiazol-4-yl)-4-(cyanomethylene)-1-(diphenylacetyl)-2-pyrrolidinecarboxamide

HRID 1349070

反応式

HRID 1349070 の反応式
C(O[C:6]([N:8]1[CH2:12][C:11](=[CH:13][C:14]#[N:15])[CH2:10][C@H:9]1[C:16]([OH:18])=O)=[O:7])(C)(C)C.[C:19]1([CH:25]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)C(Cl)=O)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.[N:35]1[S:36][N:37]=[C:38]2[C:43]([NH2:44])=[CH:42][CH:41]=[CH:40][C:39]=12>>[N:35]1[S:36][N:37]=[C:38]2[C:43]([NH:44][C:16]([C@@H:9]3[CH2:10][C:11](=[CH:13][C:14]#[N:15])[CH2:12][N:8]3[C:6](=[O:7])[CH:25]([C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=3)[C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=3)=[O:18])=[CH:42][CH:41]=[CH:40][C:39]=12

参加物

4

反応物 3

HCID 698452,1,3-Benzothiadiazol-4-amineHCID 746372,2-Diphenylacetyl chlorideHCID 69250314(2S,4EZ)-1-(tertbutoxycarbonyl)-4-(cyanomethylene)-2-pyrrolidinecarboxylic acid

生成物 1

HCID 69249372(2S,4EZ)-N-(2,1,3-benzothiadiazol-4-yl)-4-(cyanomethylene)-1-(diphenylacetyl)-2-pyrrolidinecarboxamide

実験手順

Following the general method as outlined in Example 22, startling from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(cyanomethylene)-2-pyrrolidinecarboxylic acid, diphenylacetyl chloride, and 2,1,3-benzothiadiazol-4-amine the title compound was obtained in 42% purity by LC/MS. MS(ESI+): m/z=480.4.

出典と根拠

ORDレコード
ord-128cffabf3f049ba8b3e80d302fe5d50
出典データセット
uspto-grants-2007_05
特許番号
US07211601B2

関連ノート

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