Phenyl isocyanate → (2S,4EZ)-4-[(allyloxy)imino]-N2-(9-ethyl-9H-carbazol-3-yl)-N1-phenyl-1,2-pyrrolidinedicarboxamide

HRID 1349130ノート

反応式

HRID 1349130 の反応式
[CH2:1]([O:4][N:5]=[C:6]1[CH2:10][N:9]([C:11]([O:13]C(C)(C)C)=O)[C@H:8]([C:18]([OH:20])=O)[CH2:7]1)[CH:2]=[CH2:3].[N:21]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)=C=O.[CH2:30]([N:32]1[C:44]2[CH:43]=[CH:42][C:41]([NH2:45])=[CH:40][C:39]=2[C:38]2[C:33]1=[CH:34][CH:35]=[CH:36][CH:37]=2)[CH3:31]>>[CH2:1]([O:4][N:5]=[C:6]1[CH2:10][N:9]([C:11]([NH:21][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[O:13])[C@H:8]([C:18]([NH:45][C:41]2[CH:42]=[CH:43][C:44]3[N:32]([CH2:30][CH3:31])[C:33]4[C:38]([C:39]=3[CH:40]=2)=[CH:37][CH:36]=[CH:35][CH:34]=4)=[O:20])[CH2:7]1)[CH:2]=[CH2:3]

参加物

4

反応物 3

HCID 7672Phenyl isocyanateHCID 85883-Amino-9-ethylcarbazoleHCID 58714562(2S,4EZ)-4-[(allyloxy)imino)-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid

生成物 1

HCID 131725484(2S,4EZ)-4-[(allyloxy)imino]-N2-(9-ethyl-9H-carbazol-3-yl)-N1-phenyl-1,2-pyrrolidinedicarboxamide

実験手順

Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-[(allyloxy)-imino]-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, isocyanatobenzene, and 9-ethyl-9H-carbazol-3-amine the title compound was obtained in 67% purity by LC/MS. MS(ESI+): m/z=496.4.

出典と根拠

ORDレコード
ord-be0e9b5d07ca4a7e9be2205f31950384
出典データセット
uspto-grants-2007_05
特許番号
US07211601B2

反応ノート

読み込み中…