3-Amino-9-ethylcarbazole → (2S,4EZ)-4-[(allyloxy)imino]-1-(2-ethoxy-1-naphthoyl)-N-(9-ethyl-9H-carbazol-3-yl)-2pyrrolidinecarboxamide

HRID 1349194

反応式

HRID 1349194 の反応式
[CH2:1]([O:4][N:5]=[C:6]1[CH2:10][N:9]([C:11]([O:13]C(C)(C)C)=O)[C@H:8]([C:18]([OH:20])=O)[CH2:7]1)[CH:2]=[CH2:3].[CH2:21]([O:23][C:24]1[CH:33]=[CH:32][C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[C:25]=1C(Cl)=O)[CH3:22].[CH2:37]([N:39]1[C:51]2[CH:50]=[CH:49][C:48]([NH2:52])=[CH:47][C:46]=2[C:45]2[C:40]1=[CH:41][CH:42]=[CH:43][CH:44]=2)[CH3:38]>>[CH2:1]([O:4][N:5]=[C:6]1[CH2:10][N:9]([C:11]([C:25]2[C:26]3[C:31](=[CH:30][CH:29]=[CH:28][CH:27]=3)[CH:32]=[CH:33][C:24]=2[O:23][CH2:21][CH3:22])=[O:13])[C@H:8]([C:18]([NH:52][C:48]2[CH:49]=[CH:50][C:51]3[N:39]([CH2:37][CH3:38])[C:40]4[C:45]([C:46]=3[CH:47]=2)=[CH:44][CH:43]=[CH:42][CH:41]=4)=[O:20])[CH2:7]1)[CH:2]=[CH2:3]

参加物

4

反応物 3

HCID 85883-Amino-9-ethylcarbazoleHCID 1086791-Naphthalenecarbonyl chloride, 2-ethoxy-HCID 58714562(2S,4EZ)-4-[(allyloxy)imino)-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid

生成物 1

HCID 131726379(2S,4EZ)-4-[(allyloxy)imino]-1-(2-ethoxy-1-naphthoyl)-N-(9-ethyl-9H-carbazol-3-yl)-2pyrrolidinecarboxamide

実験手順

Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-[(allyloxy)-imino]-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, 2-ethoxy-1-naphthoyl chloride, and 9-ethyl-9H-carbazol-3-amine the title compound was obtained in 60% purity by LC/MS. MS(ESI+): m/z=575.4.

出典と根拠

ORDレコード
ord-48db491425e745669c2b33ccb12c68a8
出典データセット
uspto-grants-2007_05
特許番号
US07211601B2

関連ノート

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