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(1S)-2-amino-1-phenylethan-1-ol → (2S,4EZ)-N-[(2S)-2-hydroxy-2-phenylethyl]-4-(methoxyimino)-1-[4-(3-pyridinyl)benzoyl]-2-pyrrolidinecarboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (1S)-2-amino-1-phenylethan-1-ol | HCID 643217 | — |
| 反応物 | 4-Pyridin-3-yl-benzoic acid | HCID 1515244 | — |
| 反応物 | (2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid | HCID 58714586 | — |
| 生成物 | (2S,4EZ)-N-[(2S)-2-hydroxy-2-phenylethyl]-4-(methoxyimino)-1-[4-(3-pyridinyl)benzoyl]-2-pyrrolidinecarboxamide | HCID 131725586 | — |
反応手順
Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 4-(3-pyridinyl)benzoic acid, and (1S)-2-amino-1-phenylethanol, the title compound was obtained in 73% purity by HPLC. MS(ESI+): m/z=459.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07211601B2 |
| 出典データセット | uspto-grants-2007_05 |
| ORD ID | ord-80d4db63ffec48f8984b0a5d50572329 |
| 出典メモ | uspto-grants-2007_05 |