2-(2-Methyl-2-nitropropyl)naphthalene → alpha,alpha-Dimethyl-2-naphthaleneethanamine
反応式
[CH3:1][C:2]([N+:15]([O-])=O)([CH3:14])[CH2:3][C:4]1[CH:13]=[CH:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=1>[Ni].C(O)C>[CH3:14][C:2]([NH2:15])([CH3:1])[CH2:3][C:4]1[CH:13]=[CH:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=1参加物
4
実験手順
Raney nickel W2 (200 mg) was suspended in ethanol (10 ml), to the suspension was added 2-(2-methyl-2-nitropropyl)naphthalene (134 mg) obtained in Step 5, and hydrogenation was performed at a pressure of 3.5 atom for 12 hr. The reaction mixture was filtered through Celite and concentrated under reduced pressure. The obtained residue was subjected to crystallization from ethyl acetate to give the title compound (70 mg).
後処理
- filtrationThe reaction mixture was filtered through Celite
- concentrationconcentrated under reduced pressure
- customThe obtained residue was subjected to crystallization from ethyl acetate
出典と根拠
- ORDレコード
- ord-07b27963acc749de823d3fa04bf7a4d8
- 出典データセット
- uspto-grants-2007_05
- 特許番号
- US07211685B2
反応ノート
読み込み中…