Methyl 9-benzyloxy-2-(3-chlorobenzyl)-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazine-7-carboxylate → Methyl 2-(3-chlorobenzyl)-1,8-dioxo-9-hydroxy-1,3,4,8-tetrahydro-2h-pyrido[1,2-a]pyrazine-7-carboxylate
反応式
C(OC1C(=O)C(Br)=CN2CCN(CC3C=CC=C(Cl)C=3)C(=O)C=12)C1C=CC=CC=1.C([O:37][C:38]1[C:39](=[O:61])[C:40]([C:57]([O:59][CH3:60])=[O:58])=[CH:41][N:42]2[CH2:47][CH2:46][N:45]([CH2:48][C:49]3[CH:54]=[CH:53][CH:52]=[C:51]([Cl:55])[CH:50]=3)[C:44](=[O:56])[C:43]=12)C1C=CC=CC=1>>[Cl:55][C:51]1[CH:50]=[C:49]([CH:54]=[CH:53][CH:52]=1)[CH2:48][N:45]1[CH2:46][CH2:47][N:42]2[CH:41]=[C:40]([C:57]([O:59][CH3:60])=[O:58])[C:39](=[O:61])[C:38]([OH:37])=[C:43]2[C:44]1=[O:56]参加物
反応物 2
生成物 1
実験手順
By subjecting 9-benzyloxy-7-bromo-2-(3-chlorobenzyl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione (600 mg) produced by the same method as in Example 249, Step 1 to a reaction operation similar to that in Example 161, Step 3, a mixture of methyl 9-benzyloxy-2-(3-chlorobenzyl)-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazine-7-carboxylate and methyl 2-(3-chlorobenzyl)-1,8-dioxo-9-hydroxy-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazine-7-carboxylate was obtained (13 mg). This mixture was dissolved in dimethylformamide (17 ml) and treated with benzyl bromide (1.36 g) and potassium carbonate (1.75 g) and purified by silica gel column chromatography (ethyl acetate-chloroform:methanol=10:1) to give methyl 9-benzyloxy-2-(3-chlorobenzyl)-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazine-7-carboxylate (480 mg).
後処理
- customproduced by the same method as in Example 249, Step 1 to a reaction operation similar to that in Example 161, Step 3
出典と根拠
- ORDレコード
- ord-35beb3b9099b4af6a8333c8e64adfadd
- 出典データセット
- uspto-grants-2007_05
- 特許番号
- US07211572B2
反応ノート
読み込み中…