Hydrazine → Glycine, N,N-diethyl-, hydrazide

HRID 1349830

反応式

HRID 1349830 の反応式
[CH2:1]([N:3]([CH2:9][CH3:10])[CH2:4][C:5](OC)=[O:6])[CH3:2].[NH2:11][NH2:12]>C(O)C>[NH2:11][NH:12][C:5](=[O:6])[CH2:4][N:3]([CH2:9][CH3:10])[CH2:1][CH3:2]

参加物

4

反応物 2

HCID 9321HydrazineHCID 559451N,N-Diethylglycine Methyl Ester

生成物 1

HCID 200751Glycine, N,N-diethyl-, hydrazide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of methyl 2-(diethylamino)acetate (4.167 mL, 27.55 mmol) in 4 mL of anhydrous ethanol was added anhydrous hydrazine (1.336 mL, 27.55 mmol). The solution was heated to reflux temperature overnight. The solvent was then removed under reduced pressure and the product was isolated as an oil in a quantitative yield and was used without further purification: 1H NMR (CDCl3) δ 8.3 (br s, 1H), 3.83 (br s, 2H), 3.08 (s, 2H), 2.51 (q, 4H), 1.00 (t, 6H); ES-MS (m/z) 146 [M+H]+.

後処理

  1. temperatureThe solution was heated
  2. temperatureto reflux temperature overnight
  3. customThe solvent was then removed under reduced pressure
  4. customthe product was isolated as an oil in a quantitative yield
  5. customwas used without further purification

出典と根拠

ORDレコード
ord-9888618e2be340a280c468cf52496c88
出典データセット
uspto-grants-2007_05
特許番号
US07211594B2

関連ノート

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