Ethyl formate → HCID 21094283、化合物

HRID 1350074ノート

反応式

HRID 1350074 の反応式
Cl.[NH2:2][CH2:3][CH:4]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([O:15][CH3:16])[CH:10]=1)[C:5]([O:7][CH3:8])=[O:6].[CH:17](OCC)=[O:18]>C(OCC)(=O)C>[CH:17]([NH:2][CH2:3][CH:4]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([O:15][CH3:16])[CH:10]=1)[C:5]([O:7][CH3:8])=[O:6])=[O:18]

参加物

4

反応物 2

HCID 8025Ethyl formateHCID 21094281HCID 21094281、化合物

生成物 1

HCID 21094283HCID 21094283、化合物

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

The compound obtained in Step B (20.25 g; 0.08 mol), in the form of a base, is dissolved in 130 ml of ethyl formate (1.81 mol). The reaction mixture is heated at reflux for 6 hours and then evaporated under reduced pressure. The oil obtained is taken up in ethyl acetate. The organic phase is washed with basic water (NaHCO3), dried over magnesium sulphate, filtered and evaporated to yield the title product in the form of a yellow oil.

後処理

  1. temperatureThe reaction mixture is heated
  2. temperatureat reflux for 6 hours
  3. customevaporated under reduced pressure
  4. customThe oil obtained
  5. washThe organic phase is washed with basic water (NaHCO3)
  6. dry with materialdried over magnesium sulphate
  7. filtrationfiltered
  8. customevaporated

出典と根拠

ORDレコード
ord-5d40ec6490de4f3690e319ecf629a268
出典データセット
uspto-grants-2007_05
特許番号
US07214689B2

反応ノート

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