Water → 1-Carbomethoxy-2-benzylamino-3,4-dihydronaphthalene

HRID 1350192ノート

反応式

HRID 1350192 の反応式
[C:1]([CH:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH2:8][CH2:7][C:6]1=O)([O:3][CH3:4])=[O:2].C(O)(=O)C(C)C.[CH2:22]([NH2:29])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1.O>C1(C)C=CC=CC=1>[C:1]([C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH2:8][CH2:7][C:6]=1[NH:29][CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)([O:3][CH3:4])=[O:2]

参加物

6

反応物 4

HCID 962WaterHCID 6590Isobutyric AcidHCID 7504BenzylamineHCID 5991311-Naphthalenecarboxylic acid, 1,2,3,4-tetrahydro-2-oxo-, methyl ester

生成物 1

HCID 210946731-Carbomethoxy-2-benzylamino-3,4-dihydronaphthalene収率 102.4%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To a solution of 1-carbomethoxy-2-oxo-1,2,3,4-tetrahydronaphthalene (10.2 g) and isobutyric acid (4.84 g) in toluene (150 mL) stirring at room temperature under argon, was added benzylamine (5.35 g). The resulting mixture was heated to reflux for 2 h with water removal using a Dean-Stark trap. The solvent was then evaporated under vacuum to provide the title compound (15 g) as a yellow gum.

後処理

  1. temperatureThe resulting mixture was heated
  2. customThe solvent was then evaporated under vacuum

出典と根拠

ORDレコード
ord-e1562b7a1b0342efa5869dca9cb48120
出典データセット
uspto-grants-2007_05
特許番号
US07214704B2

反応ノート

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