4-Piperidineethanol → 2-[1-(6-Chloro-2-quinolyl)-4-piperidyl]ethanol

HRID 1350573ノート

反応式

HRID 1350573 の反応式
Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:12])[CH:8]=2)[N:3]=1.[NH:13]1[CH2:18][CH2:17][CH:16]([CH2:19][CH2:20][OH:21])[CH2:15][CH2:14]1>>[Cl:12][C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][CH:6]=1)[N:3]=[C:2]([N:13]1[CH2:18][CH2:17][CH:16]([CH2:19][CH2:20][OH:21])[CH2:15][CH2:14]1)[CH:11]=[CH:10]2

参加物

3

反応物 2

HCID 739534-PiperidineethanolHCID 6075022,6-Dichloroquinoline

生成物 1

HCID 210969262-[1-(6-Chloro-2-quinolyl)-4-piperidyl]ethanol

実験手順

The process is performed as described in Example 4 (step 4.1). Starting with 2 g (10.10 mmol) of 2,6-dichloroquinoline and 1.44 g (11.10 mmol) of 2-(4-piperidyl)ethanol, and after chromatography on silica gel, eluting with a 98/2 mixture of dichloromethane and methanol, 2.54 g of pure product are obtained in the form of a white solid.

後処理

  1. washafter chromatography on silica gel, eluting with a 98/2 mixture of dichloromethane and methanol, 2.54 g of pure product
  2. customare obtained in the form of a white solid

出典と根拠

ORDレコード
ord-3a92dc86b6ff4b31a1a564e77d29ddeb
出典データセット
uspto-grants-2007_05
特許番号
US07214798B2

反応ノート

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