3-Azido-4-methylbenzoic acid → 3-Azido-N-[3-methanesulfonylamino-2-methoxy-5-(1-methyl-cyclopropyl)-phenyl]-4-methyl-benzamide

HRID 1350708ノート

反応式

HRID 1350708 の反応式
N(C1C=C(C=CC=1C)C(O)=O)=[N+]=[N-].NC1C(OC)=C(NS(C)(=O)=O)C=C(C2(C)CC2)C=1.[N:32]([C:35]1[CH:36]=[C:37]([CH:58]=[CH:59][C:60]=1[CH3:61])[C:38]([NH:40][C:41]1[CH:46]=[C:45]([C:47]([CH3:50])([CH3:49])[CH3:48])[CH:44]=[C:43]([NH:51][S:52]([CH3:55])(=[O:54])=[O:53])[C:42]=1[O:56][CH3:57])=[O:39])=[N+:33]=[N-:34]>>[N:32]([C:35]1[CH:36]=[C:37]([CH:58]=[CH:59][C:60]=1[CH3:61])[C:38]([NH:40][C:41]1[CH:46]=[C:45]([C:47]2([CH3:49])[CH2:50][CH2:48]2)[CH:44]=[C:43]([NH:51][S:52]([CH3:55])(=[O:53])=[O:54])[C:42]=1[O:56][CH3:57])=[O:39])=[N+:33]=[N-:34]

参加物

4

反応物 3

HCID 179730913-Azido-4-methylbenzoic acidHCID 210792023-azido-N-(5-tert-butyl-3-methanesulfonylamino-2-methoxy-phenyl)-4-methyl-benzamideHCID 22025264N-[3-amino-2-methoxy-5-(1-methyl-cyclopropyl)-phenyl]-methanesulfonamide

生成物 1

HCID 210972993-Azido-N-[3-methanesulfonylamino-2-methoxy-5-(1-methyl-cyclopropyl)-phenyl]-4-methyl-benzamide

実験手順

3-Azido-N-[3-methanesulfonylamino-2-methoxy-5-(1-methyl-cyclopropyl)-phenyl]-4-methyl-benzamide was prepared from 3-azido-4-methyl benzoic acid and N-[3-amino-2-methoxy-5-(1-methyl-cyclopropyl)-phenyl]-methanesulfonamide in the same manner as 3-azido-N-(5-tert-butyl-3-methanesulfonylamino-2-methoxy-phenyl)-4-methyl-benzamide (Example 15).

出典と根拠

ORDレコード
ord-a24d631e6efe4e14839b1b9ae9f25060
出典データセット
uspto-grants-2007_05
特許番号
US07214802B2

反応ノート

読み込み中…