Ethyl Acetoacetate → 1-Cyclopropyl-5-methyl-1H-pyrazole-4-carbaldehyde

反応式

C(OCC)(=O)CC(C)=O.C(O)(=O)C(O)=O.NN.[CH:18]1([C:21]2[N:25]([CH:26]([CH3:28])[CH3:27])[N:24]=[CH:23][C:22]=2[CH:29]=[O:30])CC1>>[CH:26]1([N:25]2[C:21]([CH3:18])=[C:22]([CH:29]=[O:30])[CH:23]=[N:24]2)[CH2:27][CH2:28]1

参加物

反応物 3

HCID 8868Ethyl Acetoacetate

HCID 14693824Oxalic acid--hydrazine (1/1)

HCID 196201355-cyclopropyl-1-(propan-2-yl)-1H-pyrazole-4-carbaldehyde

生成物 1

HCID 210972421-Cyclopropyl-5-methyl-1H-pyrazole-4-carbaldehyde

実験手順

1-Cyclopropyl-5-methyl-1H-pyrazole-4-carbaldehyde was prepared with ethyl acetoacetate and cylclopropyl hydrazine oxalate (Gever, G. and Hayes, K. J. Org. Chem, 1949, 14, 813–818) in the same manner as 5-cyclopropyl-1-isopropyl-1H-pyrazole-4-carbaldehyde (Example 49).

出典と根拠

ORDレコード: ord-b58cc3307c954e3190a9400c623c9756
出典データセット: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07214802B2

反応ノート

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