2,3-Dihydro-5-methoxy-1,1-dimethyl-1H-indene → HCID 23014065、化合物

HRID 1350853ノート

反応式

HRID 1350853 の反応式
C[O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[C:8]([CH3:13])([CH3:12])[CH2:7][CH2:6]2.ClCCl.B(Br)(Br)Br>ClCCl>[CH3:12][C:8]1([CH3:13])[C:9]2[C:5](=[CH:4][C:3]([OH:2])=[CH:11][CH:10]=2)[CH2:6][CH2:7]1

参加物

4

反応物 2

HCID 221522852,3-Dihydro-5-methoxy-1,1-dimethyl-1H-indeneHCID 22277759Boron tribromide dichloromethane

生成物 1

HCID 23014065HCID 23014065、化合物収率 101.4%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a stirred solution of 5-methoxy-1,1-dimethylindane (941 mg, 5.34 mmol) in anhydrous dichloromethane (20 ml) was added 1.0 M boron tribromide dichloromethane solution (10.7 ml, 10.7 mmol) via a syringe at −78° C. The mixture was warmed to ambient temperature and stirred for 1.5 hours. The mixture was quenched with water (15 ml) and extracted with dichloromethane. The combined solution was washed with brine, dried over sodium sulfate. After filtration to separate solvent and sodium sulfate, the solvent was removed under reduced pressure to give 878 mg of the crude 1,1-dimethylindan-5-ol as a gray solid.

後処理

  1. customThe mixture was quenched with water (15 ml)
  2. extractionextracted with dichloromethane
  3. washThe combined solution was washed with brine
  4. dry with materialdried over sodium sulfate
  5. filtrationAfter filtration
  6. customto separate solvent and sodium sulfate
  7. customthe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-f14d9b846dcc4df29719b9627ab33c71
出典データセット
uspto-grants-2007_05
特許番号
US07214824B2

反応ノート

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