Sulfuric Acid → 2-Phenoxyethanol Ether

HRID 1351045

反応式

HRID 1351045 の反応式
[O:1]([CH2:8][CH2:9][OH:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[K+].S(=O)(=O)(O)O>>[O:1]([CH2:8][CH2:9][OH:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:3][CH2:2][O:1][CH2:8][CH3:9]

参加物

4

反応物 3

HCID 1118Sulfuric AcidHCID 14797Potassium HydroxideHCID 31236Phenoxyethanol

生成物 1

HCID 694146262-Phenoxyethanol Ether

反応条件

温度
110 °C

実験手順

To a clean, dry stirred tank pressure vessel with nitrogen inlet is charged 1419.53 g (10.27 moles) of 2-Phenoxyethanol and a catalytic amount (16.67 g) of 45% KOH. The vessel is purged with nitrogen and heated to 110° C. Vacuum is applied for 1 hour to remove trace amounts of water and the temperature is raised to 150° C. Propylene Oxide in the amount of 3580.47 g (61.65 moles) is added at a constant rate to keep the pressure below 50 psig. After all Propylene Oxide is added, the reaction mixture is allowed to react for an additional hour after which the temperature is lowered to 110° C. and vacuum is applied for one hour. The reaction mixture is cooled to 65° C. and the catalyst is neutralized with an equivalent molar amount of 25% Sulfuric Acid.

後処理

  1. customTo a clean, dry
  2. customThe vessel is purged with nitrogen
  3. customto remove trace amounts of water
  4. temperaturethe temperature is raised to 150° C
  5. additionPropylene Oxide in the amount of 3580.47 g (61.65 moles) is added at a constant rate
  6. additionAfter all Propylene Oxide is added
  7. customto react for an additional hour after which the temperature
  8. customis lowered to 110° C.
  9. waitvacuum is applied for one hour
  10. temperatureThe reaction mixture is cooled to 65° C.

出典と根拠

ORDレコード
ord-442fb8f1e4af443abd898fa8a5583ea0
出典データセット
uspto-grants-2007_05
特許番号
US07217424B2

関連ノート

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