2-(Benzyl-methyl-amino)-1-(4-fluorophenyl)-ethanol → 1-(4-Fluorophenyl)-2-(methylamino)ethan-1-ol
反応式
[CH2:1]([N:8](C)[CH2:9][CH:10]([C:12]1[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=1)[OH:11])C1C=CC=CC=1>C(OCC)(=O)C.CO.[C].[Pd]>[F:18][C:15]1[CH:14]=[CH:13][C:12]([CH:10]([OH:11])[CH2:9][NH:8][CH3:1])=[CH:17][CH:16]=1参加物
4
実験手順
2-(Benzyl-methyl-amino)-1-(4-fluorophenyl)-ethanol (54.6 g) and 10% palladium-carbon (5.8 g) was stirred in ethyl acetate-methanol (3:1) (800 mL) at 50° C. under hydrogen atmosphere for three hours. The catalyst was removed by filtration, and the filtrate was concentrated. After solidifying with an ether-hexane solvent, and the title compound (25.8 g) was obtained as a colorless solid.
後処理
- customThe catalyst was removed by filtration
- concentrationthe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-d3c946016f154fe79a591d04e117764f
- 出典データセット
- uspto-grants-2007_05
- 特許番号
- US07217723B2
反応ノート
読み込み中…