Hydrogen chloride-ethyl acetate → [2-(4-Fluoro-3-methoxyphenyl)ethyl]methylamine hydrochloride

HRID 1351263ノート

反応式

HRID 1351263 の反応式
C(O[C:6](=O)[N:7]([CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([F:17])=[C:13]([O:18][CH3:19])[CH:12]=1)C)(C)(C)C.[ClH:21].C(OCC)(=O)C>C(OCC)(=O)C.C(OCC)C>[ClH:21].[F:17][C:14]1[CH:15]=[CH:16][C:11]([CH2:10][CH2:9][NH:7][CH3:6])=[CH:12][C:13]=1[O:18][CH3:19]

参加物

5

反応物 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 69413197[2-(4-Fluoro-3-methoxyphenyl)ethyl]methylcarbamic acid t-butyl ester

生成物 1

HCID 21098553[2-(4-Fluoro-3-methoxyphenyl)ethyl]methylamine hydrochloride

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of [2-(4-fluoro-3-methoxyphenyl)ethyl]methylcarbamic acid t-butyl ester (506 mg) in ethyl acetate (2 mL) was added a solution of 4N hydrochloric acid-ethyl acetate (2 mL) at room temperature and allowed to stand for 2.5 hours. The resulting solid was diluted with diethyl ether, then filtered, and washed with diethyl ether. After drying by aeration, the title compound (338 mg) was obtained as a colorless solid.

後処理

  1. filtrationfiltered
  2. washwashed with diethyl ether
  3. customAfter drying by aeration

出典と根拠

ORDレコード
ord-6aa24a190bbb48b5a545aa134e129106
出典データセット
uspto-grants-2007_05
特許番号
US07217723B2

反応ノート

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