Potassium Carbonate → (2S)-[2-(4-Fluorophenyl)-2-hydroxyethyl]methylcarbamic acid t-butyl ester

HRID 1351267ノート

反応式

HRID 1351267 の反応式
[C:1]([O:5][C:6]([N:8]([CH3:30])[CH2:9][C@@H:10]([O:18]C(=O)[C@@H](OC)C1C=CC=CC=1)[C:11]1[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CO.O>[C:1]([O:5][C:6](=[O:7])[N:8]([CH2:9][C@H:10]([C:11]1[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=1)[OH:18])[CH3:30])([CH3:4])([CH3:2])[CH3:3]

参加物

5

反応物 2

HCID 11430Potassium CarbonateHCID 86600988(2S)-methoxyphenyl acetic acid (1S)-2-(t-butoxycarbonyl-methylamino)-1-(4-fluorophenyl)ethyl ester

生成物 1

HCID 69416829(2S)-[2-(4-Fluorophenyl)-2-hydroxyethyl]methylcarbamic acid t-butyl ester

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

To a solution of (2S)-methoxyphenyl acetic acid (1S)-2-(t-butoxycarbonyl-methylamino)-1-(4-fluorophenyl)ethyl ester (the compound of Preparation Example 35) (3.6 g) in methanol (17 mL) was added potassium carbonate (1.8 g) on an ice bath. After stirring at room temperature for 30 minutes, the colorless solid that was generated by diluting with water was collected by filtration. After washing with water, and then drying by aeration, the title compound (2.35 g) was obtained as a colorless solid. The NMR data matched the racemic mixture described in Preparation Example 32.

後処理

  1. filtrationwas collected by filtration
  2. washAfter washing with water
  3. customdrying by aeration

出典と根拠

ORDレコード
ord-22caf8bad319436d96570242f9afbedd
出典データセット
uspto-grants-2007_05
特許番号
US07217723B2

反応ノート

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