7-Oxo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-sulfonyl chloride → HCID 69415009、化合物

HRID 1351277ノート

反応式

HRID 1351277 の反応式
[O:1]=[C:2]1[C:7]2[S:8][CH:9]=[C:10]([S:11](Cl)(=[O:13])=[O:12])[C:6]=2[CH2:5][CH2:4][CH2:3]1.[F:15][C:16]1[CH:21]=[CH:20][C:19]([C@@H:22]([OH:26])[CH2:23][NH:24][CH3:25])=[CH:18][CH:17]=1>>[F:15][C:16]1[CH:17]=[CH:18][C:19]([C@@H:22]([OH:26])[CH2:23][N:24]([CH3:25])[S:11]([C:10]2[C:6]3[CH2:5][CH2:4][CH2:3][C:2](=[O:1])[C:7]=3[S:8][CH:9]=2)(=[O:13])=[O:12])=[CH:20][CH:21]=1

参加物

3

反応物 2

HCID 210986857-Oxo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-sulfonyl chlorideHCID 42182667HCID 42182667、化合物

生成物 1

HCID 69415009HCID 69415009、化合物

実験手順

From 7-oxo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-sulfonyl chloride (the compound of Preparation Example 7) (286 mg) and (1R)-1-(4-fluorophenyl)-2-(methylamino)ethanol (the compound of Preparation Example 40) (212 mg), the title compound (356 mg) was obtained as a colorless solid, in the same way as Preparation Example 41. The NMR data matched the racemic mixture described in Preparation Example 48. The optical purity as measured by high performance liquid chromatography (ChiralPak AD-H, hexane:2-propanol=8:2) was >99% e.e.

後処理

  1. customthe compound of Preparation Example 40) (212 mg)

出典と根拠

ORDレコード
ord-a9f6a6b8299749c08d37ddd3583bc9f4
出典データセット
uspto-grants-2007_05
特許番号
US07217723B2

反応ノート

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