1-Amino-3-(4-chloro-phenoxy)-propan-2-ol → 7-Oxo-4,5,6,7-tetrahydro-benzo[b]thiophene-3-sulfonic acid [3-(4-chloro-phenoxy)-2-hydroxy-propyl]-amide
反応式
[NH2:1][CH2:2][CH:3]([OH:13])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][CH:7]=1.[O:14]=[C:15]1[C:20]2[S:21][CH:22]=[C:23]([S:24](Cl)(=[O:26])=[O:25])[C:19]=2[CH2:18][CH2:17][CH2:16]1>>[Cl:12][C:9]1[CH:10]=[CH:11][C:6]([O:5][CH2:4][CH:3]([OH:13])[CH2:2][NH:1][S:24]([C:23]2[C:19]3[CH2:18][CH2:17][CH2:16][C:15](=[O:14])[C:20]=3[S:21][CH:22]=2)(=[O:25])=[O:26])=[CH:7][CH:8]=1参加物
3
実験手順
From 1-amino-3-(4-chloro-phenoxy)-propane-2-ol (58 mg) and 7-oxo-4,5,6,7-tetrahydro-benzo[b]thiophene-3-sulfonyl chloride (the compound of Preparation Example 7) (70 mg), a yield (45 mg) was obtained as a colorless amorphous substance, in the same way as Preparation Example 41
後処理
- customa yield (45 mg)
- customwas obtained as a colorless amorphous substance, in the same way as Preparation Example 41