(2-(4-Fluorophenyl)ethyl)(methyl)amine → 2,5-Dichlorothiophene-3-sulfonic acid [2-(4-fluorophenyl)ethyl]-methyl-amide

HRID 1351296ノート

反応式

HRID 1351296 の反応式
[Cl:1][C:2]1[S:3][C:4]([Cl:11])=[CH:5][C:6]=1[S:7](Cl)(=[O:9])=[O:8].[F:12][C:13]1[CH:18]=[CH:17][C:16]([CH2:19][CH2:20][NH:21][CH3:22])=[CH:15][CH:14]=1>>[F:12][C:13]1[CH:14]=[CH:15][C:16]([CH2:19][CH2:20][N:21]([CH3:22])[S:7]([C:6]2[CH:5]=[C:4]([Cl:11])[S:3][C:2]=2[Cl:1])(=[O:9])=[O:8])=[CH:17][CH:18]=1

参加物

3

反応物 2

HCID 120234(2-(4-Fluorophenyl)ethyl)(methyl)amineHCID 27360942,5-Dichlorothiophene-3-sulfonyl chloride

生成物 1

HCID 866009922,5-Dichlorothiophene-3-sulfonic acid [2-(4-fluorophenyl)ethyl]-methyl-amide

実験手順

From 2,5-dichlorothiophene-3-sulfonyl chloride (755 mg) and [2-(4-fluorophenyl)ethyl]methylamine (the compound of Preparation Example 14) (510 mg), the title compound (1.14 g) was obtained as a colorless oily matter, in the same way as Preparation Example 41.

出典と根拠

ORDレコード
ord-0de9213a30e64e058f93bcf1afe694d5
出典データセット
uspto-grants-2007_05
特許番号
US07217723B2

反応ノート

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