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Triethylamine → tert-Butyl 3-cyanomorpholine-4-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Trifluoroacetic anhydride | HCID 9845 | — |
| 反応物 | tert-Butyl 3-carbamoylmorpholine-4-carboxylate | HCID 21098189 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | tert-Butyl 3-cyanomorpholine-4-carboxylate | HCID 21098190 | — |
反応手順
A solution of the product of Step 2 (1 eq.) and triethylamine (2.1 eq.) in CH2Cl2 (0.1 M) was cooled to 0° C. and-trifluoroacetic anhydride (1.1 eq.) added dropwise under nitrogen. Stirring was continued 3.5 hours more at room temperature and volatiles removed in vacuo. Residues taken in EtOAc were washed with water, brine and dried over Na2SO4. Evaporation gave the title compound as a brown solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07217713B2 |
| 出典データセット | uspto-grants-2007_05 |
| ORD ID | ord-f3c939e449c645d68dd58527541c32ae |
| 出典メモ | uspto-grants-2007_05 |