HCID 10155464、化合物 → HCID 9858528、化合物

HRID 1351486ノート

反応式

HRID 1351486 の反応式
Cl[C:2]1[N:7]=[N:6][C:5]([NH:8][CH2:9][CH:10]2[CH2:15][CH2:14][N:13]([C:16]([O:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[O:17])[CH2:12][CH2:11]2)=[CH:4][CH:3]=1.[H][H]>C(O)C.[Ni]>[N:7]1[CH:2]=[CH:3][CH:4]=[C:5]([NH:8][CH2:9][CH:10]2[CH2:15][CH2:14][N:13]([C:16]([O:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[O:17])[CH2:12][CH2:11]2)[N:6]=1

参加物

5

反応物 2

HCID 10155464HCID 10155464、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 9858528HCID 9858528、化合物

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 702Ethanol溶媒

実験手順

Benzyl 4-{[(6-chloro-3-pyridazinyl)amino]methyl}-1piperidinecarboxylate (EXAMPLE 22) (400 mg, 1.11 mmol) was dissolved in absolute ethanol. Raney nickel (65 mg, 1.11 mmol) was then added and the resulting reaction was stirred under 1 atm hydrogen for 18 h. The catalyst was filtered and the filtrate was concentrated under reduced pressure. The resulting clear oil was purified by silica gel chromatography to give the title compound as a clear oil.

後処理

  1. customthe resulting reaction
  2. filtrationThe catalyst was filtered
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. customThe resulting clear oil was purified by silica gel chromatography

出典と根拠

ORDレコード
ord-7f4b5e06d6294421a5ff38c99bd1b0ac
出典データセット
uspto-grants-2007_05
特許番号
US07217716B2

反応ノート

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