化工社化工社 化学情報印刷レポート · 研究参考用
Triethylamine → 5-(4-Methylpiperazin-1-yl)-2-nitroaniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 反応物 | 1-Methylpiperazine | HCID 53167 | — |
| 反応物 | 5-Fluoro-2-nitroaniline | HCID 75399 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 5-(4-Methylpiperazin-1-yl)-2-nitroaniline | HCID 2760034 | — |
反応手順
A solution of N-methylpiperazine (1.0 eq), NMP, triethylamine (3.0 eq) and 5-fluoro-2-nitrophenylamine (1.0 eq) were heated at 90° C. for 1 hours. The reaction was allowed to cool to room temperature and then poured into water and let stand for 12 hours. The resulting solid was collected and dried and utilized without further purification. MH+=237.3.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07728010B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-912e0e0b843a42cba63f5551c1645ee6 |
| 出典メモ | uspto-grants-2010_06 |