Cyclohexanol → 2-Cyclohexyloxy-5-methanesulfonyl-benzoic acid

HRID 1352248ノート

反応式

HRID 1352248 の反応式
Cl[C:2]1[CH:10]=[CH:9][C:8]([S:11]([CH3:14])(=[O:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[CH:15]1([OH:21])[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1>>[CH:15]1([O:21][C:2]2[CH:10]=[CH:9][C:8]([S:11]([CH3:14])(=[O:13])=[O:12])=[CH:7][C:3]=2[C:4]([OH:6])=[O:5])[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1

参加物

3

反応物 2

HCID 7966CyclohexanolHCID 23291322-Chloro-5-(methylsulphonyl)benzoic acid

生成物 1

HCID 211002212-Cyclohexyloxy-5-methanesulfonyl-benzoic acid

実験手順

Prepared in analogy to Example A1 (b) from 2-chloro-5-methanesulfonyl-benzoic acid (Example A1(a)) and cyclohexanol. The crude material was purified by preparative HPLC to yield the title compound as a white solid. MS (m/e): 297.3 ([M−H]−, 100%).

後処理

  1. customThe crude material was purified by preparative HPLC

出典と根拠

ORDレコード
ord-3ce9e7be7ff34546ab61c8b660f4b30c
出典データセット
uspto-grants-2007_05
特許番号
US07220744B2

反応ノート

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