Neopentyl alcohol → 2-(2,2-Dimethyl-propoxy)-5-methanesulfonyl-benzoic acid

反応式

Cl[C:2]1[CH:10]=[CH:9][C:8]([S:11]([CH3:14])(=[O:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[CH3:15][C:16]([CH3:20])([CH3:19])[CH2:17][OH:18]>>[CH3:15][C:16]([CH3:20])([CH3:19])[CH2:17][O:18][C:2]1[CH:10]=[CH:9][C:8]([S:11]([CH3:14])(=[O:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

参加物

反応物 2

HCID 6404Neopentyl alcohol

HCID 23291322-Chloro-5-(methylsulphonyl)benzoic acid

生成物 1

HCID 211002032-(2,2-Dimethyl-propoxy)-5-methanesulfonyl-benzoic acid

実験手順

Prepared in analogy to Example A1 (b) from 2-chloro-5-methanesulfonyl-benzoic acid (Example A1(a)) and 2,2-dimethyl-propan-1-ol. The crude material was purified by preparative HPLC to yield the title compound as a white solid. MS (m/e): 285.1 ([M−H]−, 100%).

後処理

customThe crude material was purified by preparative HPLC

出典と根拠

ORDレコード: ord-f085fec14ac748d995463b5766602f77
出典データセット: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07220744B2

反応ノート

読み込み中…

参加物