Piperazine → 5-Methyl-2-(piperazin-1-yl)thiazole
反応式
I[C:2]1[S:3][C:4]([CH3:7])=[CH:5][N:6]=1.[NH:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1>>[CH3:7][C:4]1[S:3][C:2]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[N:6][CH:5]=1参加物
3
実験手順
Prepared in analogy to example 2 (b) from 2-iodo-5-methyl-thiazole and piperazine. The crude material was purified by chromatography (SiO2, methanol/dichloromethane) to yield the title compound as a yellow oil (yield 32%). MS (m/e): 184.3 (M+H+, 100%).
後処理
- customThe crude material was purified by chromatography (SiO2, methanol/dichloromethane)
出典と根拠
- ORDレコード
- ord-b611228972734f4c8a8d171ece5f94ad
- 出典データセット
- uspto-grants-2007_05
- 特許番号
- US07220744B2
反応ノート
読み込み中…