Diethyl disulfide → 4-(5-Ethylsulfanyl-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester

HRID 1352315

反応式

HRID 1352315 の反応式
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[S:15][C:16](Br)=[CH:17][N:18]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:20]([S:22]SCC)[CH3:21]>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[S:15][C:16]([S:22][CH2:20][CH3:21])=[CH:17][N:18]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

参加物

3

反応物 2

HCID 8077Diethyl disulfideHCID 34180719Tert-butyl 4-(5-bromo-1,3-thiazol-2-yl)piperazine-1-carboxylate

生成物 1

HCID 684067764-(5-Ethylsulfanyl-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester収率 86%

実験手順

Prepared in analogy to example 4 (b) from 4-(5-bromo-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester (Example 4(a)) and diethyl disulphide. The crude material was purified by chromatography (SiO2, ethyl acetate/heptane) to afford the title compound as a white crystalline solid (yield 86%). MS (m/e): 330.3 (M+H+, 100%).

後処理

  1. customThe crude material was purified by chromatography (SiO2, ethyl acetate/heptane)

出典と根拠

ORDレコード
ord-df82ae43cd314053849c8ae2fa57d49b
出典データセット
uspto-grants-2007_05
特許番号
US07220744B2

関連ノート

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