Piperazine → 1-(4,5-Dimethyl-1,3-thiazol-2-yl)piperazine

HRID 1352319ノート

反応式

HRID 1352319 の反応式
I[C:2]1[S:3][C:4]([CH3:8])=[C:5]([CH3:7])[N:6]=1.[NH:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1>>[CH3:7][C:5]1[N:6]=[C:2]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[S:3][C:4]=1[CH3:8]

参加物

3

反応物 2

HCID 4837PiperazineHCID 21100233Thiazole, 2-iodo-4,5-dimethyl-

生成物 1

HCID 199157651-(4,5-Dimethyl-1,3-thiazol-2-yl)piperazine収率 25%

実験手順

Prepared in analogy to example 2 (b) from 2-iodo-4,5-dimethyl-thiazole and piperazine. The crude material was purified by chromatography (SiO2, methanol/dichloromethane) to yield the title compound as a yellow crystalline solid (yield 25%). MS (m/e): 198.3 (M+H+, 100%).

後処理

  1. customThe crude material was purified by chromatography (SiO2, methanol/dichloromethane)

出典と根拠

ORDレコード
ord-44e2950f1c8f4699b6fe396b17f9de1e
出典データセット
uspto-grants-2007_05
特許番号
US07220744B2

反応ノート

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