Hydrochloric Acid → 1-[5-(Propane-2-sulfonyl)-thiazol-2-yl]-piperazine hydrochloride
反応式
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[S:15][C:16]([S:19]([CH:22]([CH3:24])[CH3:23])(=[O:21])=[O:20])=[CH:17][N:18]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:25]>>[ClH:25].[CH3:24][CH:22]([S:19]([C:16]1[S:15][C:14]([N:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)=[N:18][CH:17]=1)(=[O:20])=[O:21])[CH3:23]参加物
3
実験手順
Prepared in analogy to example 4 (d) from 4-[5-(propane-2-sulfonyl)-thiazol-2-yl]-piperazine-1-carboxylic acid tert-butyl ester and hydrogen chloride solution. The crude material was purified by recrystallisation from ether to afford the title compound as a white crystalline solid (yield 97%). MS (m/e): 276.4 (M+H+, 100%).
後処理
- customThe crude material was purified by recrystallisation from ether
出典と根拠
- ORDレコード
- ord-52f72b96263d44c1ad5b18fe11fffb50
- 出典データセット
- uspto-grants-2007_05
- 特許番号
- US07220744B2
反応ノート
読み込み中…