1-Piperazinecarbothioamide → 1-[4-(2,2,2-Trifluoro-ethyl)-thiazol-2-yl]-piperazine

HRID 1352350ノート

反応式

HRID 1352350 の反応式
[N:1]1([C:7](=[S:9])[NH2:8])[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Br[CH2:11][C:12](=O)[CH2:13][C:14]([F:17])([F:16])[F:15]>>[F:15][C:14]([F:17])([F:16])[CH2:13][C:12]1[N:8]=[C:7]([N:1]2[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]2)[S:9][CH:11]=1

参加物

3

反応物 2

HCID 47396381-PiperazinecarbothioamideHCID 211002021-Bromo-4,4,4-trifluoro-2-butanone

生成物 1

HCID 211001721-[4-(2,2,2-Trifluoro-ethyl)-thiazol-2-yl]-piperazine収率 24%

実験手順

Prepared in analogy to example 49 (a) from 1-piperazinecarbothioamide and 1-bromo-4,4,4-trifluoro-butan-2-one. The crude material was purified by chromatography (SiO2, methanol/dichloromethane) to yield the title compound as a brown oil (yield 24%). MS (m/e): 252.3 (M+H+, 100%).

後処理

  1. customThe crude material was purified by chromatography (SiO2, methanol/dichloromethane)

出典と根拠

ORDレコード
ord-eedcf6cd32484b7e84ee966bda90eaca
出典データセット
uspto-grants-2007_05
特許番号
US07220744B2

反応ノート

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