1-(5-Trifluoromethyl-thiazol-2-yl)-piperazine hydrochloride → HCID 21100230、化合物

HRID 1352359ノート

反応式

HRID 1352359 の反応式
[CH:1]1([CH2:4][O:5][C:6]2[CH:14]=[CH:13][C:12]([S:15]([CH3:18])(=[O:17])=[O:16])=[CH:11][C:7]=2[C:8]([OH:10])=O)[CH2:3][CH2:2]1.Cl.[F:20][C:21]([F:34])([F:33])[C:22]1[S:26][C:25]([N:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)=[N:24][CH:23]=1>>[CH:1]1([CH2:4][O:5][C:6]2[CH:14]=[CH:13][C:12]([S:15]([CH3:18])(=[O:17])=[O:16])=[CH:11][C:7]=2[C:8]([N:30]2[CH2:31][CH2:32][N:27]([C:25]3[S:26][C:22]([C:21]([F:34])([F:20])[F:33])=[CH:23][N:24]=3)[CH2:28][CH2:29]2)=[O:10])[CH2:2][CH2:3]1

参加物

3

反応物 2

HCID 211002001-(5-Trifluoromethyl-thiazol-2-yl)-piperazine hydrochlorideHCID 211002282-Cyclopropylmethoxy-5-methanesulfonyl-benzoic acid

生成物 1

HCID 21100230HCID 21100230、化合物収率 22%

実験手順

Prepared in analogy to example 1 (b) from 2-cyclopropylmethoxy-5-methanesulfonyl-benzoic acid (Example A5) and 1-(5-trifluoromethyl-thiazol-2-yl)-piperazine hydrochloride (Example 58(c)). The crude material was purified by chromatography (SiO2, ethyl acetate/heptane) followed by trituration in pentane to yield the title compound as a white crystalline solid (yield 22%). MS (m/e): 490.3 (M+H+, 100%).

後処理

  1. customThe crude material was purified by chromatography (SiO2, ethyl acetate/heptane)

出典と根拠

ORDレコード
ord-f4e30618e31a46d483524aa0a6cbb471
出典データセット
uspto-grants-2007_05
特許番号
US07220744B2

反応ノート

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