1-[5-(2,2,2-Trifluoro-ethyl)-thiazol-2-yl]-piperazine hydrochloride → [5-Methanesulfonyl-2-(2,2,2-trifluoro-1,1-dimethyl-ethoxy)-phenyl]-{4-[5-(2,2,2-trifluoro-ethyl)-thiazol-2-yl]-piperazin-1-yl}-methanone
反応式
[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([O:14][C:15]([CH3:21])([CH3:20])[C:16]([F:19])([F:18])[F:17])=[C:9]([CH:13]=1)[C:10]([OH:12])=O)(=[O:4])=[O:3].Cl.[F:23][C:24]([F:38])([F:37])[CH2:25][C:26]1[S:30][C:29]([N:31]2[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]2)=[N:28][CH:27]=1>>[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([O:14][C:15]([CH3:20])([CH3:21])[C:16]([F:18])([F:17])[F:19])=[C:9]([C:10]([N:34]2[CH2:35][CH2:36][N:31]([C:29]3[S:30][C:26]([CH2:25][C:24]([F:38])([F:23])[F:37])=[CH:27][N:28]=3)[CH2:32][CH2:33]2)=[O:12])[CH:13]=1)(=[O:4])=[O:3]参加物
3
反応物 2
生成物 1
実験手順
Prepared in analogy to example 1 (b) from 5-methanesulfonyl-2-(2,2,2-trifluoro-1,1-dimethyl-ethoxy)-benzoic acid (Example A14) and 1-[5-(2,2,2-trifluoro-ethyl)-thiazol-2-yl]-piperazine hydrochloride (Example 69(e)). The crude material was purified by chromatography (SiO2, ethyl acetate/heptane) to yield the title compound as a white crystalline solid (yield 27%). MS (m/e): 560.3 (M+H+, 100%).