Thiophenol → HCID 21100324、化合物

HRID 1352384ノート

反応式

HRID 1352384 の反応式
I[CH:2]([CH3:8])[CH2:3][C:4]([F:7])([F:6])[F:5].[C:9]1([SH:15])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O.CCOCC>[F:5][C:4]([F:7])([F:6])[CH2:3][CH:2]([S:15][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH3:8]

参加物

6

反応物 3

HCID 7969ThiophenolHCID 11430Potassium CarbonateHCID 5738733-Iodo-1,1,1-trifluorobutane

生成物 1

HCID 21100324HCID 21100324、化合物収率 79%

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 6228Dimethylformamide溶媒

実験手順

To a solution of 54.9 mmol 3-iodo-1,1,1-trifluorobutane in 50 ml N,N-dimethylformamide were added 49.9 mmol thiophenol and 74.9 mmol potassium carbonate. The mixture was ultrasonicated at room temperature for 90 min. The reaction mixture was then diluted with ether and was washed three times with water. The organic phase was dried over sodium sulfate and concentrated in vacuo to afford the title compound as a colourless oil (yield 79%). MS (m/e): 221.3 (M+, 15%).

後処理

  1. customThe mixture was ultrasonicated at room temperature for 90 min
  2. washwas washed three times with water
  3. dry with materialThe organic phase was dried over sodium sulfate
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-45ca531e5a9b450790c87a223523ae67
出典データセット
uspto-grants-2007_05
特許番号
US07220744B2

反応ノート

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