2-Bromoethanol → 3-[1-(2-hydroxyethyl)piperidin-4-yl]-2H-isoquinolin-1-one

反応式

Cl.[NH:2]1[CH2:7][CH2:6][CH:5]([C:8]2[NH:9][C:10](=[O:18])[C:11]3[C:16]([CH:17]=2)=[CH:15][CH:14]=[CH:13][CH:12]=3)[CH2:4][CH2:3]1.Br[CH2:20][CH2:21][OH:22]>>[OH:22][CH2:21][CH2:20][N:2]1[CH2:7][CH2:6][CH:5]([C:8]2[NH:9][C:10](=[O:18])[C:11]3[C:16]([CH:17]=2)=[CH:15][CH:14]=[CH:13][CH:12]=3)[CH2:4][CH2:3]1

参加物

反応物 2

HCID 108982-Bromoethanol

HCID 230821133-(Piperidin-4-yl)isoquinolin-1(2H)-one hydrochloride

生成物 1

HCID 103334413-[1-(2-hydroxyethyl)piperidin-4-yl]-2H-isoquinolin-1-one収率 34.5%

実験手順

By the reaction in the same manner as in Example 2a, using 3-(piperidin-4-yl)-2H-isoquinolin-1-one hydrochloride (1.1 g) and 2-bromoethanol (1.0 g) as starting materials, 3-[1-(2-hydroxyethyl)piperidin-4-yl]-2H-isoquinolin-1-one (0.39 g) was obtained.

後処理

customBy the reaction in the same manner as in Example 2a

出典と根拠

ORDレコード: ord-251154eae59d45009e88b74e4314df55
出典データセット: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07220759B2

反応ノート

読み込み中…

参加物