N,N-Dimethylaniline → 2,6-Di(propan-2-yl)phenyl carbonochloridate

HRID 1353175ノート

反応式

HRID 1353175 の反応式
[C:1]([Cl:4])(Cl)=[O:2].[CH3:5][CH:6]([C:8]1[CH:9]=[CH:10][CH:11]=[C:12]([CH:15]([CH3:17])[CH3:16])[C:13]=1[OH:14])[CH3:7].CN(C)C1C=CC=CC=1>>[CH:15]([C:12]1[CH:11]=[CH:10][CH:9]=[C:8]([CH:6]([CH3:7])[CH3:5])[C:13]=1[O:14][C:1]([Cl:4])=[O:2])([CH3:17])[CH3:16]

参加物

4

反応物 3

HCID 949N,N-DimethylanilineHCID 4943PropofolHCID 6371Phosgene

生成物 1

HCID 2716192,6-Di(propan-2-yl)phenyl carbonochloridate

反応条件

温度
0 °C

実験手順

Phosgene (13 mL, 20% in toluene) was added to propofol (3.6 g, 20 mmol) under a nitrogen atmosphere. The mixture was cooled to 0° C. and N,N-dimethylaniline (3.3 mL, 26 mmol) was added dropwise. The reaction mixture was allowed to warm to room temperature slowly and stirred for 14 h. The solvent was removed in vacuo. The crude product was carried to next step without further purification.

後処理

  1. temperatureto warm to room temperature slowly
  2. customThe solvent was removed in vacuo
  3. customThe crude product was carried to next step without further purification

出典と根拠

ORDレコード
ord-3a3bb6e61312458e836096027f049d39
出典データセット
uspto-grants-2007_05
特許番号
US07220875B2

反応ノート

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