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Water → Ethyl (2-formamido-5-chlorothiazol-4-yl)glyoxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Chlorosuccinimide | HCID 31398 | — |
| 反応物 | Ethyl 2-(formylamino)-alpha-oxo-4-thiazoleacetate | HCID 2733245 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Ethyl (2-formamido-5-chlorothiazol-4-yl)glyoxylate | HCID 14326717 | — |
反応手順
Ethyl 2-(Formylaminothiazol-4-yl)-2-oxoacetate (9.1 g, 39.87 mmol) (obtained from Aldrich, Milwaukee, Wis.) was slurried in 50 mL of anhydrous DMF. N-Chlorosuccinimide (5.6 g, 41.86 mmol) was added as a solid and the suspension was stirred at room temperature. After 18 hours, the reaction mixture was poured into 500 mL of water. The resulting white precipitate was filtered, washed with water and air dried to afford the title intermediate as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07728127B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-572aaac4a1614a098cd42dd318d131d2 |
| 出典メモ | uspto-grants-2010_06 |