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1-(4-(Trifluoromethyl)phenyl)piperazine → (2S)-2-methoxy-3-(4-{2-oxo-2-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-ethoxy}-phenyl)-propionic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(4-(Trifluoromethyl)phenyl)piperazine | HCID 121718 | — |
| 反応物 | (2S,1R)-2-ethoxy-3-(4-{1-[2-(4-phenoxy-phenyl)-ethylcarbamoyl]-ethoxy}-phenyl)propionic acid | HCID 9847886 | — |
| 反応物 | (2S)-3-(4-carboxymethoxy-phenyl)-2-methoxy-propionic acid ethyl ester | HCID 58864673 | — |
| 生成物 | (2S)-2-methoxy-3-(4-{2-oxo-2-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-ethoxy}-phenyl)-propionic acid | HCID 58646586 | — |
反応手順
The title compound was prepared from (2S)-3-(4-carboxymethoxy-phenyl)-2-methoxy-propionic acid ethyl ester (PREPARATION 3, step 2) and 1-(4-trifluoromethyl-phenyl)-piperazine via the same procedure used for the preparation of (2S,1R)-2-ethoxy-3-(4-{1-[2-(4-phenoxy-phenyl)-ethylcarbamoyl]-ethoxy}-phenyl)-propionic acid (Example 1, step 3) to produce a colorless oil. MS (ES) for C23H25F3NO5 [M+H]+: 467.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07220880B2 |
| 出典データセット | uspto-grants-2007_05 |
| ORD ID | ord-b411ad5f12bd4de99dbca4a1400cfe5a |
| 出典メモ | uspto-grants-2007_05 |