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HRID 1353222作成日:2026年10月27日

(4-Chlorophenyl)(phenyl)methanamine → (2S)-3-[4-({[(4-chloro-phenyl)-phenyl-methyl]-carbamoyl}-methoxy)-phenyl]-2-methoxy-propionic acid

https://huagongshe.com/reaction/1353222

反応式

関与物質

役割名称HCID仕込み量
反応物(4-Chlorophenyl)(phenyl)methanamineHCID 409810—
反応物(2S,1R)-2-ethoxy-3-(4-{1-[2-(4-phenoxy-phenyl)-ethylcarbamoyl]-ethoxy}-phenyl)propionic acidHCID 9847886—
反応物(2S)-3-(4-carboxymethoxy-phenyl)-2-methoxy-propionic acid ethyl esterHCID 58864673—
生成物(2S)-3-[4-({[(4-chloro-phenyl)-phenyl-methyl]-carbamoyl}-methoxy)-phenyl]-2-methoxy-propionic acidHCID 58646617—

反応手順

The title compound was prepared from (2S)-3-(4-carboxymethoxy-phenyl)-2-methoxy-propionic acid ethyl ester (PREPARATION 3, step 2) and C-(4-chloro-phenyl)-C-phenyl-methylamine via the same procedure used for the preparation of (2S,1R)-2-ethoxy-3-(4-{1-[2-(4-phenoxy-phenyl)-ethylcarbamoyl]-ethoxy}-phenyl)-propionic acid (Example 1, step 3) to produce a yellow oil. MS (ES) for C25H24ClNO5 [M+H]+: 454.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07220880B2
出典データセットuspto-grants-2007_05
ORD IDord-ce42f56585c04bc78d511f350faee07a
出典メモuspto-grants-2007_05