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7-Chloro-4-(piperazin-1-yl)quinoline → 7-Chloro-4-[4-(3,4-difluorophenylaminocarbonyl)piperazin-1-yl]quinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 7-Chloro-4-(piperazin-1-yl)quinoline | HCID 738389 | — |
| 反応物 | 3,4-Difluorophenyl isocyanate | HCID 2734708 | — |
| 反応物 | Ethyl acetate hexane | HCID 21226206 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 7-Chloro-4-[4-(3,4-difluorophenylaminocarbonyl)piperazin-1-yl]quinoline | HCID 21101762 | — |
反応手順
7-Chloro-4-(piperazin-1-yl)quinoline (0.16 g, 0.65 mmol) and 3,4-difluorophenyl isocyanate (76 μL, 0.65 mmol) in THF (10 mL) are reacted according to method C yielding the title product as a colorless foam after column chromatography with hexane-EtOAc.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07220856B2 |
| 出典データセット | uspto-grants-2007_05 |
| ORD ID | ord-002734f2b38147448f485034a9f8a25a |
| 出典メモ | uspto-grants-2007_05 |