2-Tolyl isocyanate → 7-Chloro-4-[4-(2-methylphenylaminocarbonyl)piperazin-1-yl]quinoline

HRID 1353364ノート

反応式

HRID 1353364 の反応式
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:12]3[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]3)=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[C:18]1([CH3:27])[C:19]([N:24]=[C:25]=[O:26])=[CH:20][CH:21]=[CH:22][CH:23]=1>C(Cl)Cl>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:12]3[CH2:17][CH2:16][N:15]([C:25]([NH:24][C:19]4[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=4[CH3:27])=[O:26])[CH2:14][CH2:13]3)=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 691942-Tolyl isocyanateHCID 7383897-Chloro-4-(piperazin-1-yl)quinoline

生成物 1

HCID 211017597-Chloro-4-[4-(2-methylphenylaminocarbonyl)piperazin-1-yl]quinoline

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

7-Chloro-4-(piperazin-1-yl)quinoline (62 mg, 0.25 mmol) and o-tolyl isocyanate (31 μL, 0.25 mmol) in CH2Cl2 (5 mL) are reacted according to method C yielding the title product as colorless solid.

出典と根拠

ORDレコード
ord-6257209c864f419aa4535fbde737e486
出典データセット
uspto-grants-2007_05
特許番号
US07220856B2

反応ノート

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