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4-Methylcyclohexylamine → 7-Chloro-4-[4-[(4-methylcyclohexyl)aminocarbonyl]piperazin-1-yl]quinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Methylcyclohexylamine | HCID 80604 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 4-Nitrophenyl chloroformate | HCID 82129 | — |
| 反応物 | 7-Chloro-4-(piperazin-1-yl)quinoline | HCID 738389 | — |
| 溶媒 | Dichloromethane methanol | HCID 21226129 | — |
| 生成物 | 7-Chloro-4-[4-[(4-methylcyclohexyl)aminocarbonyl]piperazin-1-yl]quinoline | HCID 21101730 | — |
反応手順
As described for example 78, 4-methylcyclohexylamine (206.1 mg, 1.82 mmol), 4-nitrophenyl chloroformate (366 mg, 1.82 mmol), diisopropyl(ethyl)amine (554 mg, 4.3 mmol), and 7-chloro-4-(piperazin-1-yl)quinoline (300 mg, 1.21 mmol) are reacted affording the title product after flash chromatography with CH2Cl2-MeOH.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07220856B2 |
| 出典データセット | uspto-grants-2007_05 |
| ORD ID | ord-90e7e55c012340a89f5ffca740f1d2f0 |
| 出典メモ | uspto-grants-2007_05 |