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Water → 1-(4-Formylbenzoyl)-4-isopropylpiperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Toluene | HCID 1140 | — |
| 反応物 | 1-Isopropylpiperazine | HCID 78013 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | 4-Formylbenzoyl chloride | HCID 12424620 | — |
| 生成物 | 1-(4-Formylbenzoyl)-4-isopropylpiperazine | HCID 57478581 | — |
反応手順
A solution of 4-formyl-benzoyl chloride (2.80, 16.65 mol) (prepared as in Example 1 above) in toluene (43.3 g, 469.39 mmol) was added slowly to a solution of NaHCO3 (0.8 g, 9.52 mmol) and 4-isopropylpiperazine (2.50 g, 18.35 mmol) in water (5 g, 277 mmol) at 0° C. The reaction mixture was vigorously stirred until the reaction was deemed complete. The layers were split and the toluene phase was concentrated to yield the title compound as a yellow oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07728129B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-12c0f95a39454b7eb5c209df9b63506f |
| 出典メモ | uspto-grants-2010_06 |