Hydrazine → Piracetam hydrazide

HRID 1353887

反応式

HRID 1353887 の反応式
[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][C:8]([O:10]C)=O.[NH2:12][NH2:13]>C(O)C>[NH2:12][NH:13][C:8](=[O:10])[CH2:7][N:3]1[CH2:4][CH2:5][CH2:6][C:2]1=[O:1]

参加物

4

反応物 2

HCID 9321HydrazineHCID 108835Methyl 2-oxo-1-pyrrolidineacetate

生成物 1

HCID 3565593Piracetam hydrazide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of methyl 2-(2-oxopyrrolidinyl)acetate (0.884 mL, 6.36 mmol) in 1 mL of anhydrous ethanol was added anhydrous hydrazine (0.308 mL, 6.36 mmol). The solution was heated to reflux temperature overnight. The solvent was then removed under reduced pressure and the product was isolated as a solid in a quantitative yield and was used without further purification: 1H NMR (CDCl3) δ 8.17 (br s, 1H), 3.94 (s, 2H), 3.55 (t, 2H), 2.43 (t, 2H), 2.10 (quintet, 2H); ES-MS (m/z) 158 [M+H]+.

後処理

  1. temperatureThe solution was heated
  2. temperatureto reflux temperature overnight
  3. customThe solvent was then removed under reduced pressure
  4. customthe product was isolated as a solid in a quantitative yield
  5. customwas used without further purification

出典と根拠

ORDレコード
ord-81e1c2e895cf42f6ad52314f673d7a0d
出典データセット
uspto-grants-2007_05
特許番号
US07220771B2

関連ノート

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